Article

The Role of the Ubiquitin-Proteasome Pathway in Oncogenic

2002-07-09

Abstract excerpt

Oncogenic activation of genes that regulate cell proliferation and survival plays a central role in the development of human cancer. This activation is frequently achieved by the aberrant expression of oncogene products due to the gene amplification, enhanced transcription or stabilization of their mRNA or protein. The ubiquitin-proteasome pathway (UPP) is the key player in the intracellular degradation of regulat...

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Literature Corpus work: 6e3acca7-8582-5016-a337-3acb6a8a8806
DOI: 10.4161/cbt.1.4.2

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