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MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells

5 Jan 2024

Abstract excerpt

The oncogenic MUC1-C transmembrane protein is a critical effector of the cancer stem cell (CSC) state. Addiction to MUC1-C for self-renewal in the progression of human cancers has emphasized the need for development of anti-MUC1-C agents. However, there are presently no approved small molecules for targeting MUC1-C-dependent CSCs. In screening for small molecules, we identified salinomycin (SAL), an inducer of...

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PMID: 38182558
DOI: 10.1038/s41420-023-01772-9

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