Article
The absence of seroconversion after exposition to hepatitis C virus is not related to KIR-HLA genotype combinations (GEHEP-012 study).
Antiviral research - 1 Feb 2024
Martín-Sierra Carmen, Bravo María José, Sáez María Eugenia, De Rojas Itziar, Santos Marta, Martín-Carmona Jesica, Corma-Gómez Anaïs, González-Serna Alejandro, Royo José Luis, Pineda Juan A, Rivero Antonio, Rivero-Juárez Antonio, Macías Juan, Real Luis Miguel
Abstract excerpt
BACKGROUND & AIMS: It has been reported that specific killer-cell immunoglobulin-like receptors (KIRs) and HLA genotype combinations, such as KIR2DS4/HLA-C1 with presence of KIRDL2 or KIRDL3, homozygous KIRDL3/HLA-C1 and KIR3DL1/≥2HLA-Bw4, are strongly associated with the lack of active infection and seroconversion after exposition to hepatitis C virus (HCV). OBJECTIVE: To determine whether these KIR-HLA...
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