Article
Neural stem cell homeostasis is affected in cortical organoids carrying a mutation in Angiogenin.
The Journal of pathology - 1 Apr 2024
Ferguson Ross, van Es Michael A, van den Berg Leonard H, Subramanian Vasanta
Abstract excerpt
Mutations in Angiogenin (ANG) and TARDBP encoding the 43 kDa transactive response DNA binding protein (TDP-43) are associated with amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). ANG is neuroprotective and plays a role in stem cell dynamics in the haematopoietic system. We obtained skin fibroblasts from members of an ALS-FTD family, one with mutation in ANG, one with mutation in both TARDBP...
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