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Article

Obesity phenotype induced by high-fat diet promotes diethylnitrosamine (DEN)-induced precancerous lesions by M1 macrophage polarization in mice liver.

The Journal of nutritional biochemistry - 1 Mar 2024

Tian Li, Zuoqin Du, Jiaqi Wu, Xiaomeng Jin, Xin Deng, Yan Yang, Youkun Zheng, Jianbo Wu

Abstract excerpt

Liver precancerous lesions are the key to improving the efficacy of cancer treatment because of the extremely poor prognosis of HCC patients in moderate and late stages. Obesity-related HCC progression is closely related to the inflammatory microenvironment, in which macrophages are one of the major constituents. In the present study, we ask whether obesity promotes diethylnitrosamine (DEN)-induced precancerous...

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Source

Identifiers

PMID: 38176623
DOI: 10.1016/j.jnutbio.2023.109566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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