Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromosomal mosaicism in human blastocysts: the ultimate challenge of preimplantation genetic testing?

16 Apr 2018

Abstract excerpt

STUDY QUESTION: To what extent does a trophectoderm (TE) biopsy reliably reflect the chromosomal constitution of the inner cell mass (ICM) in human blastocysts? SUMMARY ANSWER: Concordance between TE and ICM was established in 62.1% of the embryos analysed. WHAT IS KNOWN ALREADY: Next generation sequencing (NGS) platforms have recently been optimised for preimplantation genetic testing for aneuploidies (PGT-A)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genomic variations and chromosomal abnormalities
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29796631
DOI: 10.1093/humrep/dey106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosomal mosaicism in human blastocysts: the ultimate challenge of preimplantation genetic testing?PMID 29796631Read ↗

Chromosomal mosaicism in human blastocysts: a cytogenetic comparison of trophectoderm and inner cell mass after next-generation sequencingSemantic proximity Read ↗

Chromosomal mosaicism in human blastocysts: the ultimate diagnostic dilemmaSemantic proximity Read ↗

The true incidence of chromosomal mosaicism after preimplantation genetic testing is much lower than that indicated by trophectoderm biopsySemantic proximity Read ↗

Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsySemantic proximity Read ↗

Assessment of aneuploidy concordance between clinical trophectoderm biopsy and blastocystSemantic proximity Read ↗

Segmental aneuploidy in human embryos is frequently mosaic with evidence of meiotic origin: insights from trophectoderm and inner cell mass analyses.Semantic proximity Read ↗

Regional and developmental characteristics of human embryo mosaicism revealed by single cell sequencingSemantic proximity Read ↗

Detection and quantitation of chromosomal mosaicism in human blastocysts using copy number variation sequencingSemantic proximity Read ↗

Aligning genotyping and copy number data in single trophectoderm biopsies for aneuploidy prediction: uncovering incomplete concordanceSemantic proximity Read ↗

Concordance between different trophectoderm biopsy sites and the inner cell mass of chromosomal composition measured with a next-generation sequencing platformSemantic proximity Read ↗

Comprehensive analysis of karyotypic mosaicism between trophectoderm and inner cell massSemantic proximity Read ↗

Detection of mosaicism at blastocyst stage with the use of high-resolution next-generation sequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.