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Article

A novel grading system combining histological grade and CDKN2A homozygous and hemizygous deletion to predict prognosis in IDH-mutant astrocytoma.

Journal of neuropathology and experimental neurology - 19 Jan 2024

Xi Shaoyan, Huang Qitao, Zeng Jing

Abstract excerpt

Isocitrate dehydrogenase (IDH)-mutant astrocytoma with microvascular proliferation, necrosis, CDKN2A/B homozygous deletion, or any combination of these features corresponds to World Health Organization grade 4 according to current criteria. However, the prognostic significance of CDKN2A hemizygous deletion in IDH-mutant astrocytoma is not well established. We undertook a comprehensive study that included...

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PMID: 38175671
DOI: 10.1093/jnen/nlad112

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