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Article

Effect of TET2 on the pathogenesis of diabetic nephropathy through activation of transforming growth factor β1 expression via DNA demethylation.

Life sciences - 15 Aug 2018

Yang Liling, Zhang Qian, Wu Qiong, Wei Yi, Yu Jiawei, Mu Jiao, Zhang Jun, Zeng Wei, Feng Bing

Abstract excerpt

AIMS: Transforming growth factor β1 (TGFβ1) plays a pivotal role in the pathogenesis of diabetic nephropathy (DN). However, the mechanism of its expression and activation induced by high glucose (HG) is still unclear. We mainly explored the role of ten-eleven translocation enzyme-2 (TET2) in regulating TGFβ1 expression in the process of DN. MAIN METHODS: Human mesangial cells (HMCs) and db/db mice were used to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29705354
DOI: 10.1016/j.lfs.2018.04.044

Genes

TET2

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