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Article

Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis

11 Apr 2017

Abstract excerpt

Proliferative diabetic retinopathy (PDR) is a common cause of blindness in the developed world’s working adult population and affects those with type 1 and type 2 diabetes. We identified Runt-related transcription factor 1 (RUNX1) as a gene upregulated in CD31+ vascular endothelial cells obtained from human PDR fibrovascular membranes (FVMs) via transcriptomic analysis. In vitro studies using human retinal...

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PMID: 28400392
DOI: 10.2337/db16-1035

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