Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of TET2-mediated ROBO4 hypomethylation in the development of diabetic retinopathy

10 Jul 2023

Abstract excerpt

BACKGROUND: In diabetic retinopathy, increasing evidence points to a link between the pathogenesis of retinal microangiopathy and the endothelial cell-specific factor roundabout4 (ROBO4). According to earlier research, specificity protein 1 (SP1) enhances the binding to the ROBO4 promoter, increasing Robo4 expression and hastening the progression of diabetic retinopathy. To determine if this is related to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Axon Guidance and Neuronal Signaling
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37430272
DOI: 10.1186/s12967-023-04310-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of TET2-mediated ROBO4 hypomethylation in the development of diabetic retinopathyPMID 37430272Read ↗

TET2-mediated ECM1 hypomethylation promotes the neovascularization in active proliferative diabetic retinopathySemantic proximity Read ↗

Enhanced ROBO4 is mediated by up‐regulation of HIF‐1α/SP1 or reduction in miR‐125b‐5p/miR‐146a‐5p in diabetic retinopathySemantic proximity Read ↗

Role of histone modification and DNA methylation in signaling pathways involved in diabetic retinopathySemantic proximity Read ↗

DNA methylation in diabetic retinopathy: pathogenetic role and potential therapeutic targetsSemantic proximity Read ↗

Identification and Validation of Genes Related to RNA Methylation Modification in Diabetic RetinopathySemantic proximity Read ↗

Diabetic retinopathy: reversibility of epigenetic modifications and new therapeutic targetsSemantic proximity Read ↗

Contribution of epigenetics in diabetic retinopathySemantic proximity Read ↗

Effect of TET2 on the pathogenesis of diabetic nephropathy through activation of transforming growth factor β1 expression via DNA demethylation.Semantic proximity Read ↗

Epigenetic Modification of Mitochondrial DNA in the Development of Diabetic RetinopathySemantic proximity Read ↗

Diabetes Promotes Retinal Vascular Endothelial Cell Injury by Inducing CCN1 ExpressionSemantic proximity Read ↗

The Role of DNA Methylation in the Metabolic Memory Phenomenon Associated With the Continued Progression of Diabetic RetinopathySemantic proximity Read ↗

Endothelial Cell–Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact VasculatureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.