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CD38 gene polymorphism rs1130169 contribution to the increased gene expression and risk of colorectal cancer (pilot study).

Molecular biology reports - 3 Jan 2024

Novikov Dmitry V, Perenkov Alexei D, Shumilova Svetlana V, Kubysheva Nailya I, Novikov Viktor V

Abstract excerpt

BACKGROUND: Genetic variations in immune signaling genes may have regulatory effect on phenotypic heterogeneity of immune cells and immune functions, hence promoting tumor growth. PURPOSE: We compared the frequencies of potentially functional CD38 gene single nucleotide polymorphisms rs1130169 (T > C) in 86 healthy controls and 90 colorectal cancer (CRC) cases to assess their association with cancer risk and CD38...

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PMID: 38170288
DOI: 10.1007/s11033-023-09034-8

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