Article
MENTSH: A novel mitochondrial microprotein linked to a SNP associated with type 2 diabetes.
Theranostics - 1 Jan 2026
Yen Kelvin, Ramirez Ricardo, Miller Brendan, Kumagai Hiroshi, Yao Jie, Levine Morgan, Guo Xiuqing, Sha Jihui, Silverstein Ana, Vicinanza Roberto, Taylor Kent D, Flores Melanie, Reyna Zeferino, Kim Su-Jeong, Guerrero Noel, Mehta Hemal H, Wan Junxiang, Niu Zhongzheng, Breton Carrie V, Kenney Maria C, Arpawong Thalida Em, Wohlschlegel James, Rotter Jerome I, Crimmins Eileen, Cohen Pinchas
Abstract excerpt
Rationale: Obesity and type 2 diabetes (T2D) are growing threats to human health, and their genetic basis is complex and not fully understood. Furthermore, the mitochondrial genome has been shown to encode for many microproteins that have a variety of biological effects. In this study we explore a newly discovered mitochondrial-derived microprotein (MDP) that may be responsible for some forms of diabetes in...
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