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Article

Characterizing the protective effects of SHLP2, a mitochondrial-derived peptide, in macular degeneration

5 Oct 2018

Abstract excerpt

Mitochondrial-derived peptides (MDPs) are rapidly emerging therapeutic targets to combat development of neurodegenerative diseases. SHLP2 (small humanin-like peptide 2) is a newly discovered MDP that is coded from the MT-RNR2 (Mitochondrially encoded 16S rRNA) gene in mitochondrial DNA (mtDNA). In the current study, we examined the biological consequences of treatment with exogenously-added SHLP2 in an in vitro...

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PMID: 30310092
DOI: 10.1038/s41598-018-33290-5

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