Article
Simplified molecular classification of lung adenocarcinomas based on EGFR, KRAS, and TP53 mutations.
BMC cancer - 31 Jan 2020
Ruiz-Cordero Roberto, Ma Junsheng, Khanna Abha, Lyons Genevieve, Rinsurongkawong Waree, Bassett Roland, Guo Ming, Routbort Mark J, Zhang Jianjun, Skoulidis Ferdinandos, Heymach John, Roarty Emily B, Tang Zhenya, Medeiros L Jeffrey, Patel Keyur P, Luthra Rajyalakshmi, Roy-Chowdhuri Sinchita
Abstract excerpt
BACKGROUND: Gene expression profiling has consistently identified three molecular subtypes of lung adenocarcinoma that have prognostic implications. To facilitate stratification of patients with this disease into similar molecular subtypes, we developed and validated a simple, mutually exclusive classification. METHODS: Mutational status of EGFR, KRAS, and TP53 was used to define seven mutually exclusive...
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