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Iodoquinazoline-derived VEGFR-2 and EGFRT790M dual inhibitors: Design, synthesis, molecular docking and anticancer evaluations.

Bioorganic chemistry - 1 Feb 2024

Mohamed Abeer A, El-Hddad Sanadelaslam S A, Aljohani Ahmed K B, Khedr Fathalla, Alatawi Omar M, Keshek Doaa E, Ahmed Sahar, Alsulaimany Marwa, Almadani Sara A, El-Adl Khaled, Hanafy Noura S

Abstract excerpt

Herein, we report the synthesis of a series of new fourteen iodoquinazoline derivatives 7a-c to 13a-e and their evaluation as potential anticancer agents via dual targeting of EGFRT790M and VEGFR-2. The new derivatives were designed according to the target receptors structural requirements. The compounds were evaluated for their cytotoxicity against HepG2, MCF-7, HCT116 and A549 cancer cell lines using MTT assay....

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Identifiers

PMID: 38150938
DOI: 10.1016/j.bioorg.2023.107062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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