Article
2-Thioxo-3,4-dihydropyrimidine and thiourea endowed with sulfonamide moieties as dual EGFRT790M and VEGFR-2 inhibitors: Design, synthesis, docking, and anticancer evaluations.
Drug development research - 1 Feb 2024
El-Gaby Mohamed S A, Abdel Reheim Mohamed A M, Akrim Zuhir S M, Naguib Bassem H, Saleh Nashwa M, El-Adasy Abu Bakr A A M, El-Adl Khaled, Mohamady Samy
Abstract excerpt
The effectiveness of a new series of thiopyrimidine and thiourea containing sulfonamides moieties was tested on HCT-116, MCF-7, HepG2, and A549. HepG2 cell line was the one that all the new derivatives affected the most. The greatest potent compounds against the four HepG2, HCT116, MCF-7, and A549 cell lines were 8f and 8g with IC50 = 4.13, 6.64, 5.74, 6.85 µM and 4.09, 4.36, 4.22, 7.25 µM correspondingly....
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