Article
Development of Novel Class of Phenylpyrazolo[3,4-d]pyrimidine-Based Analogs with Potent Anticancer Activity and Multitarget Enzyme Inhibition Supported by Docking Studies.
International journal of molecular sciences - 9 Oct 2023
Aljohani Ahmed K B, El Zaloa Waheed Ali Zaki, Alswah Mohamed, Seleem Mohamed A, Elsebaei Mohamed M, Bayoumi Ashraf H, El-Morsy Ahmed M, Almaghrabi Mohammed, Awaji Aeshah A, Hammad Ali, Alsulaimany Marwa, Ahmed Hany E A
Abstract excerpt
Phenylpyrazolo[3,4-d]pyrimidine is considered a milestone scaffold known to possess various biological activities such as antiparasitic, antifungal, antimicrobial, and antiproliferative activities. In addition, the urgent need for selective and potent novel anticancer agents represents a major route in the drug discovery process. Herein, new aryl analogs were synthesized and evaluated for their anticancer effects...
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