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Design and synthesis of novel pyrazolopyrimidine candidates as promising EGFR-T790M inhibitors and apoptosis inducers.

Future medicinal chemistry - 1 Oct 2023

Gaber Ahmed A, Sharaky Marwa, Elmaaty Ayman Abo, Hammouda Mohamed M, Mourad Ahmed Ae, Elkhawaga Samy Y, Mokhtar Mahmoud Mohamed, Abouzied Amr S, Mourad Mai Ae, Al-Karmalawy Ahmed A

Abstract excerpt

Aim: Our objective was to design and synthesize a new range of pyrazolopyrimidines while maintaining the key pharmacophoric features of EGFR tyrosine kinase inhibitors. Materials & methods: Percentage inhibition in 14 human cancer cell lines and IC50 values were recorded. Compounds 6c, 7e and 7f were examined against both wild and mutant (T790M) EGFR subtypes. Apoptosis markers, cell cycle arrest, apoptosis assay...

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Identifiers

PMID: 37882053
DOI: 10.4155/fmc-2023-0156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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