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Article

Discovery of new thieno[2,3-d]pyrimidines as EGFR tyrosine kinase inhibitors for cancer treatment.

Future medicinal chemistry - 1 Jul 2023

Sobh Eman A, Dahab Mohammed A, Elkaeed Eslam B, Alsfouk Aisha A, Ibrahim Ibrahim M, Metwaly Ahmed M, Eissa Ibrahim H

Abstract excerpt

Background: EGFR has been considered a vital molecular target in cancer management. Aim: The discovery of new thieno[2,3-d]pyrimidine derivatives as EGFR tyrosine kinase inhibitors. Methods: Nine derivatives were designed, synthesized and subjected to in vitro and in silico studies. Results: Compound 7a significantly inhibited the growth of HepG2 and PC3 cells for both EGFR wild-type and EGFRT790M. Compound 7a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37529910
DOI: 10.4155/fmc-2023-0086

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