Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study.

doi:10.1136/heartjnl-2023-323490

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Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study.

Heart (British Cardiac Society) - 25 Apr 2024

Tschiderer Lena, van der Schouw Yvonne T, Burgess Stephen, Bloemenkamp Kitty W M, Seekircher Lisa, Willeit Peter, Onland-Moret Charlotte, Peters Sanne A E

Abstract excerpt

OBJECTIVE: Observational studies show that hypertensive disorders of pregnancy (HDPs) are related to unfavourable maternal cardiovascular disease (CVD) risk profiles later in life. We investigated whether genetic liability to pre-eclampsia/eclampsia and gestational hypertension is associated with CVD risk factors and occurrence of CVD events. METHODS: We obtained genetic associations with HDPs from a genome-wide...

Topics

Humans
Female
Pregnancy
Mendelian Randomization Analysis
Hypertension, Pregnancy-Induced
Middle Aged
Genome-Wide Association Study
Male
Cardiovascular Diseases
United Kingdom

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Assessment

Genetic Predisposition to Disease

Risk Factors

Pre-Eclampsia

Adult

Heart Disease Risk Factors

Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 38148158
DOI: 10.1136/heartjnl-2023-323490
PMCID: PMC11103302

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