Genetic Risk and First-Trimester Cardiovascular Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women.

doi:10.1016/j.jacc.2025.02.015

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Article

Genetic Risk and First-Trimester Cardiovascular Health Predict Hypertensive Disorders of Pregnancy in Nulliparous Women.

Journal of the American College of Cardiology - 15 Apr 2025

Mathew Vineetha, Khan Raiyan R, Jowell Amanda R, Yan Qi, Pe'er Itsik, Truong Buu, Natarajan Pradeep, Yee Lynn M, Khan Sadiya S, Sharma Garima, Patel Aniruddh P, Cho So Mi Jemma, Pabon Maria A, McNeil Rebecca B, Spencer Jillyn, Silver Robert M, Levine Lisa D, Grobman William A, Catov Janet M, Haas David M, Honigberg Michael C

Abstract excerpt

BACKGROUND: Hypertensive disorders of pregnancy (HDPs) (preeclampsia/eclampsia and gestational hypertension) are a leading cause of maternal and perinatal morbidity and mortality and are associated with long-term maternal cardiovascular disease. High genetic risk and poor cardiovascular health (CVH) are each associated with HDPs, but whether genetic risk for HDP is modified by CVH status in early pregnancy is...

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Identifiers

PMID: 40204378
DOI: 10.1016/j.jacc.2025.02.015
PMCID: PMC12042077

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