Article
Generation of a human induced pluripotent stem cell line (SMUSHi002-A) from an ALS patient carrying a heterozygous mutation c.1562G > A in the FUS gene.
Stem cell research - 1 Feb 2024
Tang Mei, Xiong Min, Zhou Wenyan, Lei Jiafan, Huang Min, Huang Chunyan, Wang Fei, Liu Jun, Li Jun, Xu Xueqing
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Affected patients experience gradual loss of their spinal cord and cortical motor neurons with consequent muscle weakness and emaciation, and eventual respiratory failure. The pathogenesis of ALS remains largely unknown although the FUS (sarcoma fusion gene) gene is known to be one of the major pathogenic genes. We have generated an induced...
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