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Article

Generation of six induced pluripotent stem cell lines from patients with amyotrophic lateral sclerosis with associated genetic mutations in either FUS or ANXA11.

Stem cell research - 1 Apr 2021

Hedges Erin C, Topp Simon, Shaw Christopher E, Nishimura Agnes L

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of upper and lower motor neurons, causing gradual paralysis, and resulting in death 3-5 years from diagnosis. ALS causative mutations have been identified in multiple genes, including Fused in sarcoma (FUS), and recently characterized Annexin A11 (ANXA11). We have derived induced pluripotent stem cell (iPSC) lines from six ALS patient...

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Identifiers

PMID: 33610019
DOI: 10.1016/j.scr.2021.102246
PMCID: PMC7988463

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