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Article

Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis.

Molecular neurodegeneration - 22 Jan 2016

Lim Su Min, Choi Won Jun, Oh Ki-Wook, Xue Yuanchao, Choi Ji Young, Kim Sung Hoon, Nahm Minyeop, Kim Young-Eun, Lee Jinhyuk, Noh Min-Young, Lee Seungbok, Hwang Sejin, Ki Chang-Seok, Fu Xiang-Dong, Kim Seung Hyun

Abstract excerpt

BACKGROUND: Mutations in the fused in sarcoma (FUS) gene have been linked to amyotrophic lateral sclerosis (ALS). ALS patients with FUS mutations exhibit neuronal cytoplasmic mislocalization of the mutant FUS protein. ALS patients' fibroblasts or induced pluripotent stem cell (iPSC)-derived neurons have been developed as models for understanding ALS-associated FUS (ALS-FUS) pathology; however, pathological...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoplasmic Granules

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Share to RNA-Binding Protein FUS

Source

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Identifiers

PMID: 26795035
DOI: 10.1186/s13024-016-0075-6
PMCID: PMC4722778

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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