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Article

Generation of two induced pluripotent stem cell lines with heterozygous and homozygous amyotrophic lateral sclerosis-causing mutation R521G (c.1561C > G) in FUS gene.

Stem cell research - 1 Jun 2023

Akter Masuma, Cui Haochen, Abir Hosain Md, Ding Baojin

Abstract excerpt

Mutations in the RNA-binding protein FUS (fused in sarcoma) are linked to amyotrophic lateral sclerosis (ALS), but the pathogenesis is not fully understood. For modeling ALS, here we generated two induced pluripotent stem cell (iPSC) lines carrying the heterozygous and homozygous R521G (c.1561C > G) mutation in the FUS gene via genetic modification of a healthy hiPSC line (WTC11, UCSFi001-A). Both lines show...

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Identifiers

PMID: 36965406
DOI: 10.1016/j.scr.2023.103078
PMCID: PMC10353567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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