Article
The fused in sarcoma protein forms cytoplasmic aggregates in motor neurons derived from integration-free induced pluripotent stem cells generated from a patient with familial amyotrophic lateral sclerosis carrying the FUS-P525L mutation.
Neurogenetics - 1 Jul 2015
Liu Xinxiu, Chen Jiayu, Liu Wenchao, Li Xiaogang, Chen Qi, Liu Tao, Gao Shaorong, Deng Min
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that primarily affects motor neurons (MNs) and has no effective treatment. Mutations in the fused in sarcoma (FUS) gene and abnormal aggregation of FUS protein have been reported in ALS. However, the mechanisms involved in ALS are poorly understood. Clinical drug trails have failed due to a lack of appropriate disease models, including a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.