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Article

An intronic G run within HIV-1 intron 2 is critical for splicing regulation of vif mRNA.

Journal of virology - 1 Mar 2013

Widera Marek, Erkelenz Steffen, Hillebrand Frank, Krikoni Aikaterini, Widera Darius, Kaisers Wolfgang, Deenen René, Gombert Michael, Dellen Rafael, Pfeiffer Tanya, Kaltschmidt Barbara, Münk Carsten, Bosch Valerie, Köhrer Karl, Schaal Heiner

Abstract excerpt

Within target T lymphocytes, human immunodeficiency virus type I (HIV-1) encounters the retroviral restriction factor APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G; A3G), which is counteracted by the HIV-1 accessory protein Vif. Vif is encoded by intron-containing viral RNAs that are generated by splicing at 3' splice site (3'ss) A1 but lack splicing at 5'ss D2, which results in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp41

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Share to rev Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 23255806
DOI: 10.1128/JVI.02755-12
PMCID: PMC3571361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An intronic G run within HIV-1 intron 2 is critical for splicing regulation of vif mRNA.PMID 23255806Read ↗

Regulation of Vif mRNA splicing by human immunodeficiency virus type 1 requires 5' splice site D2 and an exonic splicing enhancer to counteract cellular restriction factor APOBEC3G.Semantic proximity Read ↗

A functional conserved intronic G run in HIV-1 intron 3 is critical to counteract APOBEC3G-mediated host restriction.Semantic proximity Read ↗

Negative and positive mRNA splicing elements act competitively to regulate human immunodeficiency virus type 1 vif gene expression.Semantic proximity Read ↗

Multiple APOBEC3 Restriction Factors for HIV-1 and One Vif to Rule Them AllSemantic proximity Read ↗

An Exonic Splicing Silencer Downstream of the 3′ Splice Site A2 Is Required for Efficient Human Immunodeficiency Virus Type 1 ReplicationSemantic proximity Read ↗

Multifaceted counter-APOBEC3G mechanisms employed by HIV-1 Vif.Semantic proximity Read ↗

Vpr14-88-Apobec3G fusion protein is efficiently incorporated into Vif-positive HIV-1 particles and inhibits viral infection.Semantic proximity Read ↗

Characterization of conserved motifs in HIV-1 Vif required for APOBEC3G and APOBEC3F interaction.Semantic proximity Read ↗

Alternative splicing: regulation of HIV‐1 multiplication as a target for therapeutic actionSemantic proximity Read ↗

Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 proteaseSemantic proximity Read ↗

Translational regulation of APOBEC3G mRNA by Vif requires its 5'UTR and contributes to restoring HIV-1 infectivity.Semantic proximity Read ↗

SF2/ASF binds to a splicing enhancer in the third HIV-1 tat exon and stimulates U2AF binding independently of the RS domain.Semantic proximity Read ↗

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