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Article

Biosynthesis of the Inner Core of Bordetella pertussis Lipopolysaccharides: Effect of Mutations on LPS Structure, Cell Division, and Toll-like Receptor 4 Activation.

International journal of molecular sciences - 9 Dec 2023

Pérez-Ortega Jesús, van Boxtel Ria, Plisnier Michel, Ingels Dominique, Devos Nathalie, Sijmons Steven, Tommassen Jan

Abstract excerpt

Previously developed whole-cell vaccines against Bordetella pertussis, the causative agent of whooping cough, appeared to be too reactogenic due to their endotoxin content. Reduction in endotoxicity can generally be achieved through structural modifications in the lipid A moiety of lipopolysaccharides (LPS). In this study, we found that dephosphorylation of lipid A in B. pertussis through the heterologous...

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Identifiers

PMID: 38139140
DOI: 10.3390/ijms242417313
PMCID: PMC10743493

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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