Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proanthocyanidins delaying the premature ovarian insufficiency through regulatory sirt1-p53-p21 signaling pathway in female germline stem cells

10 May 2025

Abstract excerpt

BACKGROUND: As women age, their ovarian follicle pool naturally declines. However, female germline stem cells (FGSCs) possess a unique ability to differentiate into oocytes and continuously self-renew, providing an effective means of delaying ovarian aging by replenishing the primordial follicle pool. Therefore, activating FGSCs is critical in reshaping and safeguarding ovarian function. METHODS: In this study,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ovarian function and disorders
Share to Reproductive Biology and Fertility
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40349064
DOI: 10.1186/s13048-025-01661-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proanthocyanidins delaying the premature ovarian insufficiency through regulatory sirt1-p53-p21 signaling pathway in female germline stem cellsPMID 40349064Read ↗

Female germline stem cells: aging and anti-agingSemantic proximity Read ↗

Melatonin as Potential Targets for Delaying Ovarian AgingSemantic proximity Read ↗

Single-Oocyte Gene Expression Suggests That Curcumin Can Protect the Ovarian Reserve by Regulating the PTEN-AKT-FOXO3a PathwaySemantic proximity Read ↗

Ovarian Stem Cell Nests in Reproduction and Ovarian AgingSemantic proximity Read ↗

Resveratrol and SIRT1: Antiaging Cornerstones for Oocytes?Semantic proximity Read ↗

Female germline stem cells: recent advances, opportunities, and challenges to overcomeSemantic proximity Read ↗

Cell-Free Fat Extract Improves Ovarian Function and Fertility in Mice With Advanced AgeSemantic proximity Read ↗

Fisetin Delays Postovulatory Oocyte Aging by Regulating Oxidative Stress and Mitochondrial Function through Sirt1 PathwaySemantic proximity Read ↗

Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidantsSemantic proximity Read ↗

The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian InsufficiencySemantic proximity Read ↗

Mechanisms of Cell Senescence and Apoptosis in Cyclophosphamide-Induced Premature Ovarian Failure in RatsSemantic proximity Read ↗

The Role of PEDF in Reproductive Aging of the OvarySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.