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Clinicopathological characteristics of multiple-classifier endometrial cancers: a cohort study and systematic review.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 5 Feb 2024

De Vitis Luigi Antonio, Schivardi Gabriella, Caruso Giuseppe, Fumagalli Caterina, Vacirca Davide, Achilarre Maria Teresa, Aloisi Alessia, Garbi Annalisa, Zanagnolo Vanna, Aletti Giovanni, Guerini-Rocco Elena, Mariani Andrea, Maggioni Angelo, Barberis Massimo, Bogani Giorgio, Colombo Nicoletta, Multinu Francesco, Betella Ilaria

Abstract excerpt

BACKGROUND: Endometrial cancers with more than one molecular feature-POLE mutations (POLEmut), mismatch repair protein deficiency (MMRd), p53 abnormality (p53abn)-are called 'multiple classifiers'. OBJECTIVE: To describe our cohort of multiple classifiers and to report the results of a review on their incidence and the techniques used to identify them. METHODS: Multiple classifiers identified at the European...

Topics

Humans
Female
Endometrial Neoplasms
Cohort Studies
Tumor Suppressor Protein p53
Mutation
Middle Aged
Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Poly-ADP-Ribose Binding Proteins

DNA Polymerase II

DNA Mismatch Repair

Source

Identifiers

PMID: 38135437
DOI: 10.1136/ijgc-2023-004864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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