Article
Clinical features of ProMisE groups identify different phenotypes of patients with endometrial cancer.
Archives of gynecology and obstetrics - 1 Jun 2021
Raffone Antonio, Travaglino Antonio, Gabrielli Olimpia, Micheli Mariacarolina, Zuccalà Valeria, Bitonti Giovanna, Camastra Caterina, Gargiulo Valentina, Insabato Luigi, Zullo Fulvio
Abstract excerpt
BACKGROUND: The Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) groups has identified four molecular prognostic groups of endometrial cancer (EC): POLE-mutated (POLE-mt), mismatch repair-deficient (MMR-d), p53-abnormal (p53-abn), p53-wild-type (p53-wt). These groups might have different pathogenesis and risk factors, and might occur in different phenotypes of patients. However, these data are...
Topics
- Aged
- Biomarkers, Tumor
- DNA Polymerase II
- Endometrial Neoplasms
- Female
- Genes, p53
- Humans
- Middle Aged
- Mutation
- PTEN Phosphohydrolase