Article
Genes differentially expressed between pathogenic and non-pathogenic Entamoeba histolytica clones influence pathogenicity-associated phenotypes by multiple mechanisms.
PLoS pathogens - 1 Dec 2023
Anders Juliett, König Constantin, Lender Corinna, Hellhund Arne, Nehls Sarah, Shalabi Ibrahim, Honecker Barbara, Lorenzen Stephan, Meyer Martin, Matthiesen Jenny, Cadar Dániel, Roeder Thomas, Galal Metwally Nahla, Lotter Hannelore, Bruchhaus Iris
Abstract excerpt
Recently, two genes involved in amoebic liver abscess formation in a mouse model were identified by their differential expression of non-pathogenic (A1np) and pathogenic (B2p) clones of the Entamoeba histolytica isolate HM:1-IMSS. While overexpression of a gene encoding the metallopeptidase EhMP8-2 reduces the virulence of the pathogenic clone B2p, overexpression of the gene ehi_127670 (ehhp127), encoding a...
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