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Article

Overexpression of Specific Cysteine Peptidases Confers Pathogenicity to a Nonpathogenic Entamoeba histolytica Clone

27 Mar 2013

Abstract excerpt

ABSTRACT Cysteine peptidases (CPs) of Entamoeba histolytica are considered to be important pathogenicity factors. Previous studies have found that under standard axenic culture conditions, only four ( ehcp-a1 , ehcp-a2 , ehcp-a5 , and ehcp-a7 ) out of 35 papain-like ehcp genes present in the E. histolytica genome are expressed at high levels. Little is known about the expression of CPs in E. histolytica during...

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PMID: 23532975
DOI: 10.1128/mbio.00072-13

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