Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia

21 Dec 2023

Abstract excerpt

BACKGROUND: Distinct endothelial cell cycle states (early G1 versus late G1) provide different “windows of opportunity” to enable the differential expression of genes that regulate venous versus arterial specification, respectively. Endothelial cell cycle control and arteriovenous identities are disrupted in vascular malformations including arteriovenous shunts, the hallmark of hereditary hemorrhagic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Vascular Anomalies and Treatments
Share to Vascular Malformations and Hemangiomas
Share to Vascular Malformations Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38126211
DOI: 10.1161/circulationaha.122.062952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic TelangiectasiaPMID 38126211Read ↗

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular LesionsSemantic proximity Read ↗

"Recent Advances in Hereditary Hemorrhagic Telangiectasia Pathogenesis and Therapies"Semantic proximity Read ↗

Nitazoxanide activates BMP9-ALK1-SMAD signaling cascade and improves HHT vascular pathologySemantic proximity Read ↗

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular LesionsSemantic proximity Read ↗

Analysis of Endothelial-to-Haematopoietic Transition at the Single Cell Level identifies Cell Cycle Regulation as a Driver of DifferentiationSemantic proximity Read ↗

Hereditary hemorrhagic telangiectasia: diagnosis and management from the hematologist's perspective.Semantic proximity Read ↗

Gene-specific endothelial programs drive AVM pathogenesis in SMAD4 and ALK1 loss-of-functionSemantic proximity Read ↗

Identifying transcriptomic downstream targets of genes commonly mutated in Hereditary Hemorrhagic TelangiectasiaSemantic proximity Read ↗

Hereditary hemorrhagic telangiectasia: an update on transforming growth factor beta signaling in vasculogenesis and angiogenesis.Semantic proximity Read ↗

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasiaSemantic proximity Read ↗

Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor.Semantic proximity Read ↗

Arterial endothelial deletion of hereditary hemorrhagic telangiectasia 2/ <i>Alk1</i> causes epistaxis and cerebral microhemorrhage with aberrant arteries and defective smooth muscle coverageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.