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Article

The puzzling mutational landscape of the SARS-2-variant Omicron.

Journal of medical virology - 1 May 2022

Fantini Jacques, Yahi Nouara, Colson Philippe, Chahinian Henri, La Scola Bernard, Raoult Didier

Abstract excerpt

The recently emerging SARS-CoV-2 variant omicron displays an unusual association of 30 mutations, 3 deletions, and 1 insertion. To analyze the impact of this atypic mutational landscape, we constructed a complete structure of the omicron spike protein. Compared with the delta variant, the receptor-binding domain (RBD) of omicron has an increased electrostatic surface potential, but a decreased affinity for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34997962
DOI: 10.1002/jmv.27577
PMCID: PMC9015223

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