Article
Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant.
Nature - 1 Mar 2022
Suzuki Rigel, Yamasoba Daichi, Kimura Izumi, Wang Lei, Kishimoto Mai, Ito Jumpei, Morioka Yuhei, Nao Naganori, Nasser Hesham, Uriu Keiya, Kosugi Yusuke, Tsuda Masumi, Orba Yasuko, Sasaki Michihito, Shimizu Ryo, Kawabata Ryoko, Yoshimatsu Kumiko, Asakura Hiroyuki, Nagashima Mami, Sadamasu Kenji, Yoshimura Kazuhisa, Sawa Hirofumi, Ikeda Terumasa, Irie Takashi, Matsuno Keita, Tanaka Shinya, Fukuhara Takasuke, Sato Kei
Abstract excerpt
The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern1. In this study, our statistical modelling suggests that Omicron has spread more rapidly than the Delta variant in several countries including South Africa. Cell culture experiments showed Omicron to be less fusogenic than Delta and than an ancestral strain of SARS-CoV-2. Although the spike (S) protein of Delta is efficiently...
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