Article
Natural killer cell functional genetics and donor-specific antibody-triggered microvascular inflammation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 May 2024
Diebold Matthias, Vietzen Hannes, Heinzel Andreas, Haindl Susanne, Herz Carsten T, Mayer Katharina, Doberer Konstantin, Kainz Alexander, Faé Ingrid, Wenda Sabine, Kühner Laura M, Berger Sarah M, Puchhammer-Stöckl Elisabeth, Kozakowski Nicolas, Schaub Stefan, Halloran Philip F, Böhmig Georg A
Abstract excerpt
Antibody-mediated rejection (ABMR) is a leading cause of graft failure. Emerging evidence suggests a significant contribution of natural killer (NK) cells to microvascular inflammation (MVI). We investigated the influence of genetically determined NK cell functionality on ABMR development and activity. The study included 86 kidney transplant recipients subjected to systematic biopsies triggered by donor-specific...
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