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Article

TgMIC6 inhibition of autophagy is partially responsible for the phenotypic differences between Chinese 1 Toxoplasma gondii strains.

International immunopharmacology - 25 Oct 2024

Wang Yang, Li Jingyang, Zhu Jinjin, Ma Haiyang, Zhuang Baocan, Zhao Ji, Zhang Famin, Yu Li

Abstract excerpt

Chinese1 is the predominant Toxoplasma gondii lineage in China, and significant phenotypic differences are observed within the lineage. WH3 and WH6 are two representative strains of Chinese 1, which exhibit divergent virulence and pathogenicity in mice. However, virulence determinants and their modulating mechanisms remain elusive. A global genome expression analysis of the WH3 and WH6 transcriptional profiles...

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PMID: 39116491
DOI: 10.1016/j.intimp.2024.112857

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