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Article

Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.

Cardiovascular research - 1 Nov 2014

Agullo-Pascual Esperanza, Lin Xianming, Leo-Macias Alejandra, Zhang Mingliang, Liang Feng-Xia, Li Zhen, Pfenniger Anna, Lübkemeier Indra, Keegan Sarah, Fenyö David, Willecke Klaus, Rothenberg Eli, Delmar Mario

Abstract excerpt

AIMS: It is well known that connexin43 (Cx43) forms gap junctions. We recently showed that Cx43 is also part of a protein-interacting network that regulates excitability. Cardiac-specific truncation of Cx43 C-terminus (mutant 'Cx43D378stop') led to lethal arrhythmias. Cx43D378stop localized to the intercalated disc (ID); cell-cell coupling was normal, but there was significant sodium current (INa) loss. We...

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Identifiers

PMID: 25139742
DOI: 10.1093/cvr/cvu195
PMCID: PMC4296112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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