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Article

Quantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instability.

The Journal of cell biology - 20 Sept 2010

Thoma Claudio R, Matov Alexandre, Gutbrodt Katrin L, Hoerner Christian R, Smole Zlatko, Krek Wilhelm, Danuser Gaudenz

Abstract excerpt

Von Hippel-Lindau (VHL) tumor suppressor gene mutations predispose carriers to kidney cancer. The protein pVHL has been shown to interact with microtubules (MTs), which is critical to cilia maintenance and mitotic spindle orientation. However, the function for pVHL in the regulation of MT dynamic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20855504
DOI: 10.1083/jcb.201006059
PMCID: PMC3101603

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20855504-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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