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Article

Profibrotic role of transcription factor SP1 in cross-talk between fibroblasts and M2 macrophages

17 Nov 2023

Abstract excerpt

Fibrosis disrupts tissue balance and links to severe illnesses, impairing organ function and, in some cases, even fatality. The interaction between M2 macrophages and fibroblasts is vital for tissue equilibrium. Transforming growth factor β1 (TGF-β1) released by M2 macrophages plays a central role in fibrosis, regulating fibroblast activity and extracellular matrix metabolism. Targeting TGF-β1 is key to fibrosis...

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PMID: 38094246
DOI: 10.1016/j.isci.2023.108484

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