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Article

Sonic Hedgehog Signaling Affected by Promoter Hypermethylation Induces Aberrant Gli2 Expression in Spina Bifida.

Molecular neurobiology - 1 Oct 2016

Lu Xiao-Lin, Wang Li, Chang Shao-Yan, Shangguan Shao-Fang, Wang Zhen, Wu Li-Hua, Zou Ji-Zhen, Xiao Ping, Li Rui, Bao Yi-Hua, Qiu Z-Y, Zhang Ting

Abstract excerpt

GLI2 is a key mediator of the sonic hedgehog (Shh) signaling pathway and plays an important role in neural tube development during vertebrate embryogenesis; however, the role of gli2 in human folate-related neural tube defects remains unclear. In this study, we compared methylation status and polymorphisms of gli2 between spina bifida patients and a control group to explore the underlying mechanisms related to...

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Share to Chromatin
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Gene Expression Regulation, Developmental

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Share to Zinc Finger Protein GLI1

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Source

Identifiers

PMID: 26446020
DOI: 10.1007/s12035-015-9447-0

Genes

GLI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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