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Article

Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin

1 Dec 2023

Abstract excerpt

Ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) DNA damage response (DDR) kinases contain elastic domains. ATM also responds to reactive oxygen species (ROS) and ATR to nuclear mechanical stress. Mre11 mediates ATM activation following DNA damage; ATM mutations cause ataxia telangiectasia (A-T). Here, using in vivo imaging, electron microscopy, proteomic, and mechano-biology...

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PMID: 38088930
DOI: 10.1016/j.celrep.2023.113555

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