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Article

SIRT6 promotes metastasis and relapse in HER2-positive breast cancer

12 Dec 2023

Abstract excerpt

The histone deacetylase sirtuin 6 (SIRT6) has been endowed with anti-cancer capabilities in many tumor types. Here, we investigate the impact of SIRT6-overexpression (SIRT6-OE) in Delta16HER2 mice, which are a bona fide model of HER2-positive breast cancer. After an initial delay in the tumor onset, SIRT6-OE induces a more aggressive phenotype of Delta16HER2 tumors promoting the formation of higher number of...

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PMID: 38081972
DOI: 10.1038/s41598-023-49199-7

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