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Article

Natural glucocorticoid receptor mutants causing generalized glucocorticoid resistance: molecular genotype, genetic transmission, and clinical phenotype.

The Journal of clinical endocrinology and metabolism - 1 Apr 2004

Charmandari Evangelia, Kino Tomoshige, Souvatzoglou Emmanuil, Vottero Alessandra, Bhattacharyya Nisan, Chrousos George P

Abstract excerpt

Glucocorticoid resistance is a rare, familial, or sporadic condition characterized by partial end-organ insensitivity to glucocorticoids. The clinical spectrum of the condition ranges from completely asymptomatic to severe hyperandrogenism, fatigue, and/or mineralocorticoid excess. The molecular basis of glucocorticoid resistance in several families and sporadic cases has been ascribed to mutations in the human...

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Identifiers

PMID: 15070967
DOI: 10.1210/jc.2003-030450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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