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Oncolytic Therapy of Solid Tumors by Modified Vesicular Stomatitis Virus

11 Dec 2023

Abstract excerpt

Vesicular stomatitis virus (VSV) is a promising oncolytic virus for treating solid tumors. We recently engineered a replicating VSV that specifically targets and destroys Her2/neu-expressing cancer cells. This virus was created by eliminating its natural binding site and adding a coding sequence for a single chain antibody to the Her2/neu receptor into its genome. Such an approach can be tailored to target...

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PMID: 38079267
DOI: 10.1089/dna.2023.0368

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