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Article

Age-related decline in spermatogenic activity accompanied with endothelial cell senescence in male mice

13 Nov 2023

Abstract excerpt

Male fertility decreases with aging, with spermatogenic decline being one of its causes. Altered testis environment is suggested as a cause of the phenotype; however, the associated mechanisms remain unclear. Herein, we investigated the age-related changes in testicular somatic cells on spermatogenic activity. The number and proliferation of spermatogonia significantly reduced with aging in mice. Interestingly,...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 38077127
DOI: 10.1016/j.isci.2023.108456

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