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In Vivo and In Vitro Aging Is Detrimental to Mouse Spermatogonial Stem Cell Function

29 Dec 2010

Abstract excerpt

The development of techniques to maintain the spermatogonial stem cell (SSC) in vivo and in vitro for extended periods essentially allows for the indefinite continuation of an individual germline. Recent evidence indicates that the aging of male reproductive function is due to failure of the SSC niche. SSCs are routinely cultured for 6 mo, and no apparent effect of culture over this period has been observed. To...

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PMID: 21191109
DOI: 10.1095/biolreprod.110.088229

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