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Article

Inhibition of miR-143-3p Restores Blood–Testis Barrier Function and Ameliorates Sertoli Cell Senescence

8 Feb 2024

Abstract excerpt

Due to the increasing trend of delayed childbirth, the age-related decline in male reproductive function has become a widely recognized issue. Sertoli cells (SCs) play a vital role in creating the necessary microenvironment for spermatogenesis in the testis. However, the mechanism underlying Sertoli cell aging is still unclear. In this study, senescent Sertoli cells showed a substantial upregulation of miR-143-3p...

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PMID: 38391926
DOI: 10.3390/cells13040313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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