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Single-cell transcriptome analyses reveal critical regulators of spermatogonial stem cell fate transitions

3 Feb 2024

Abstract excerpt

Abstract Background Spermatogonial stem cells (SSCs) are the foundation cells for continual spermatogenesis and germline regeneration in mammals. SSC activities reside in the undifferentiated spermatogonial population, and currently, the molecular identities of SSCs and their committed progenitors remain unclear. Results We performed single-cell transcriptome analysis on isolated undifferentiated spermatogonia...

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PMID: 38310206
DOI: 10.1186/s12864-024-10072-0

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